Hello, everyone! As many of you know, it has been a crazy week so far, so I am finally sitting down to write an update. On Monday, Dr. M. called to let us know that one slot had become available for the clinical trial for GDC-0084, which is the trial that we had been hoping to get into. However, we had to scramble to get up to Dana Farber within 24 hrs to get the open spot. Tuesday, we went up to Boston, met with the P.A. from the study, Ken completed the screening tests and signed the consent, so he is now officially in the study! Dr. M. had laid all the groundwork for us by having us visit Dana Farber last July so Ken was already a patient of Dr. Wen (Who is the Physician Investigator on the study), and has been forwarding all of Ken's scan results to Dr. Wen so everyone was already up to date when we arrived. As I understand it (again, I am not very scientific, so I may not have this exactly right), the drug that they are testing is specifically made to penetrate the brain (most drugs are specifically made NOT to penetrate the brain) and to block a certain mollecular pathway, thereby prohibiting the tumor from growing. That mollecular pathway is switched on by a mutation in the P13CA gene. The incredible news that I learned on Tuesday is that they have done genetic testing on Ken's actual tumor (that was removed in March) and it DID test positive for the P13CA mutation. So the doctors at Dana Farber feel quite optimistic that this drug will have a positive effect on Ken's tumor. Their ultimate goal is that while they can't actually cure this type of brain tumor, they may be able to stop it from growing and thereby successfully manage it by taking a simple pill each day, much like they now manage diabetes or high blood pressure!! Ken will begin the Clinical Trial next week. The first four days of the study he will need to remain in Boston for close monitoring. Then he will need to go up to Dana Farber several times in the first month, then it will lessen to once a week. Eventually, he will be taking the pill from home and traveling to Boston twice a month for the duration of the study. As long as he is responsive to the medication, he will remain on it indefinately. The trial is still in Phase one, which is the dosing phase. While he's not in the first control group (on the lowest dose) it is still early in the trial so it is not the most powerful dose, either. However, there is another gentleman that is on the same dosage and his most recent MRI showed no growth so we are encouraged that this is an effective dose. I asked if the dose can be increased if they eventually find that a higher dose is more effective, and they told me that after his third month they are able to increase his dose. There is, of course, a long list of possible side effects, but so far in the study no one has reported any major issues, the chief complaint is of "tiredness". I am so hopefull that Ken will tolerate the drug well, and not have the issues that he experienced during his first clinical trial. Fingers are crossed! That is ALL that I know about everything. I am trying not to get my hopes up, but that is very difficult for me because we left Dana Farber on Tuesday feeling VERY encouraged and optimistic, and extremely grateful to have this opportunity! I will try to update everyone again once the trial has started. Thank you so much to everyone for your well wishes and support!